Fifty of these patients fulfilled our criteria for PLE. In the group of patients without anti-Hu or anti-Ta antibodies, the tumour distribution was diverse, with cancer of the lung the most common (36%); 57% had positive MRI. Similarly, Carr's daughter had a full recovery in the absence of immune therapy. She is an adult who chooses to be a baby, one who does not know her own opinions and who would not express them to an authority if she did. The DSM-IV Diagnostic Criteria for PTSD provides a checklist of symptoms that may be used to detect the disorder in Ophelia. (Funded by the Canadian Cancer Society and the National Cancer Institute; HD.6 ClinicalTrials.gov number, NCT00002561.). Enter your email address to follow this blog and receive notifications of new posts by email. Magnetic resonance imaging (MRI) was normal in both patients. 18 The cases reported in the English literature are summarized in Table 3. Their cardiac assessment included physical examination, electrocardiogram (ECG), and resting and postexercise echocardiograms. "Ophelia Syndrome Commentary" Essays and Research Papers . To date, five years after initial presentation, the young man is able to walk with walking aids and orthoses and is still on oral prednisolone therapy. To read the full-text of this research, you can request a copy directly from the authors. We have reviewed the literature of immune therapy in autoimmune encephalitis associated with antibodies to cell surface antigens including N-methyl-D-aspartate receptor (NMDAR), leucine-rich, glioma-inactivated protein-1 (LGI1), contactin-associated protein-2 (Caspr2), the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), γ-aminobutyric acid-A receptor (GABAAR), γ-aminobutyric acid-B receptor (GABABR), Glycine R and other rarer antigens. HL is the third most common cause of LE after SCLC and testicular germ cell tumors. ... [106] He called this Ophelia syndrome and described resolution of the neurological symptoms with tumor treatment. [106] However, poor outcome with death in Ophelia syndrome has been reported in other cases, with [113] or without, ... Our patient's case fulfilled all the criteria required for diagnosis of Ophelia syndrome. Methods: The work is done on the basis of scientific literature search in various databases and analysis of the resulting material. It may be possible to maintain dose intensity in the face of uncomplicated neutropenia during ABVD therapy. Direct neurologic dysfunction from Hodgkin's Lymphoma results from metastatic intracranial spinal disease, epidural metastases causing spinal cord/cauda equina compression, leptomeningeal metastases, or intradural intramedullary spinal cord metastases. Based strictly on the script, her role in the story and relationship with other characters, particularly Hamlet, come off as ambiguous. It is characterized by low self esteem, anxiety, inability to take decisions and increased risk for depression — … 18 The cases reported in the English literature are summarized in Table 3. She is chronically ignorant, chronically dependent, and chronically submissive. The combination of symptoms, MRI findings and paraneoplastic antibodies established the diagnosis of PLE in 78% of the patients. Results: There was obtained information on the prevalence, typologies, risk factors and treatment of blood diseases in the available literature. Lancet. The main antibody in this group targets the metabotropic glutamate receptor 5 (mGluR5). The most frequent complications observed in this sample were essentially coronary artery disease and valvular abnormalities. Psychohematology Attempt to Summarise, Paraneoplastic neurological syndromes in Hodgkin and Non-Hodgkin lymphomas, Hodgkin's Lymphoma: A Review of Neurologic Complications, Paraneoplastic limbic encephalitis with SOX1 and PCA2 antibodies and relapsing neurological symptoms in an adolescent with Hodgkin lymphoma, Limbic encephalitis with mGluR5 antibodies and immunotherapy-responsive prosopagnosia, Hu-antibody positive limbic encephalitis in a patient with Hodgkin lymphoma, From psychiatric symptoms to paraneoplastic syndrome, Memory lost, memory regained: neuropsychological findings and neuroimaging in two cases of paraneoplastic limbic encephalitis with radically diVerent outcomes, Paraneoplastic limbic encephalitis: Neurological symptoms, immunological findings and tumor association in 50 patients, The Ophelia syndrome: Memory loss in Hodgkin's disease, Limbic encephalitis and hyperactive foci on PET scan, Pathology of pure hippocampal sclerosis in a patient with dementia and Hodgkin's disease: The Ophelia syndrome. One was later diagnosed with breast cancer and the other with lung cancer. Methods: A PET scan six months later was normal. The attraction of autoimmune neurological diseases lies in part in the ever-expanding spectrum of the antibodies and the challenging symptoms and syndromes they produce. Furthermore, the type and frequency of PNS are different between HL and NHL; while LE and PCD occur almost exclusively in patients with HL, sensorimotor neuropathies and dermatomyositis are more frequent in NHL. Chemotherapy for Hodgkin's lymphoma may cause cerebral infarction (due to emboli from anthracycline-induced cardiomyopathy) and peripheral neuropathy. Their subsequently diagnosed small cell lung cancer was treated with a combination of radiotherapy and chemotherapy, leading to remission of the tumour. On thorough cardiac assessment a mean of 21 years after their diagnosis, none of the 53 unselected asymptomatic HLS showed physical signs or significant ECG abnormalities during or after the stress echo test. Conclusions: The presented data of literature suggests clinical heterogeneity and a wide range (from asthenic reactions to delirious states) of psychopathological disorders detected in blood diseases patients. Secondly, patients given early treatment do better. Down Syndrome Analysis. The commonly associated neoplasms were of the lung (50%), testis (20%) and breast (8%). She is described as a helpless child and has a “Lord” or authoritative figure that forces her even lower to the status of an infant. It's where your interests connect you with your people. Many of these diseases include a typical movement disorder that can be a powerful aid to diagnosis. Nos résultats dans les troubles bipolaires et la schizophrénie montraient une prévalence du syndrome métabolique chez les patients respectivement de 20% et de 24%. It was a sinking moment, but not a surprising one. Timely decision to treat her underlying malignancy with chemotherapy resulted in are markable recovery in her neurological status within few weeks of treatment. In the present study, we determined the incidence of neutropenia, febrile neutropenia, and the relationship of febrile neutropenia to grade III/IV neutropenia, Purpose: PET scans obtained in the interictal state showed right hippocampal hypermetabolism in both patients. After radiochemotherapy, the lymphoma subsided except for involvement of the spleen, but the dementia remained. Various databases and analysis of the CSF and serum revealed anti SOX-1 antibodies at initial presentation PCA-2. Cancer Society and the National cancer Institute ; HD.6 ClinicalTrials.gov number, NCT00002561... 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